Added default exclusion path for path which usually are unwanted for loading animation:

admin/*
panels/*
node/*/panelizer/*
js/*
ajax/*

jquery_loadinganimation.admin.inc

-<?php
-
-/**
- * @file
- * JQuery Loadinganimation admin/configuration functionality.
- */
-
-/**
- * jquery_loadinganimation admin settings form.
- */
-function jquery_loadinganimation_settings_form() {
-  $module_path = drupal_get_path('module', 'jquery_loadinganimation');
-  $img_src_default = $module_path . '/images/ajax-loader.gif';
-  $form['jquery_loadinganimation_show_on_ajax'] = array(
-    '#type' => 'checkbox',
-    '#title' => t('Show during AJAX requests'),
-    '#description' => t(
-        "Display the loading animation during AJAX requests too. Notice: Use with caution, may be disturbing."),
-    '#default_value' => variable_get('jquery_loadinganimation_show_on_ajax', FALSE));
-  $form['jquery_loadinganimation_show_on_form_submit'] = array(
-    '#type' => 'checkbox',
-    '#title' => t('Show after form submission'),
-    '#description' => t("Display the loading animation on form submit. <em>Important:</em> Buttons with further JS events registered are excluded from this trigger."),
-    '#default_value' => variable_get(
-        'jquery_loadinganimation_show_on_form_submit', TRUE));
-  $form['jquery_loadinganimation_show_on_href'] = array(
-    '#type' => 'checkbox',
-    '#title' => t('Show on href click'),
-    '#description' => t(
-        "Display the loading animation after a link has been clicked."),
-    '#default_value' => variable_get('jquery_loadinganimation_show_on_href', TRUE));
-  $form['jquery_loadinganimation_subselector'] = array(
-    '#type' => 'textfield',
-    '#title' => t('JQuery subselector'),
-    '#description' => t(
-        "You may optionally use this subselector to reduce the DOM context which to register loading animation to."),
-    '#required' => FALSE,
-    '#default_value' => variable_get('jquery_loadinganimation_subselector', ''));
-  // Exclude
-  $form['jquery_loadinganimation_path_match_exclude'] = array(
-    '#type' => 'textarea',
-    '#title' => t('Exclude the following path(s)'),
-    '#description' => t(
-        "jQuery Loadinganimation will not be used for paths that match these patterns.") . ' ' . t("Specify pages by using their paths. Enter one path per line. The '*' character is a wildcard. Example paths are %blog for the blog page and %blog-wildcard for every personal blog. %front is the front page.") . ' ' . t("Default: 'admin/*'"),
-    '#required' => TRUE,
-    '#default_value' => variable_get('jquery_loadinganimation_path_match_exclude', 'admin/*'));
-  $form['jquery_loadinganimation_close_on_click'] = array(
-    '#type' => 'checkbox',
-    '#title' => t('Close on layer click'),
-    '#description' => t(
-        "Close the layer if user clicks on it while loading process is still in progress."),
-    '#default_value' => variable_get('jquery_loadinganimation_close_on_click', TRUE));
-  $form['jquery_loadinganimation_close_on_esc'] = array(
-    '#type' => 'checkbox',
-    '#title' => t('Close on ESC press'),
-    '#description' => t(
-        "Close the layer if user presses ESC while loading process is still in progress."),
-    '#default_value' => variable_get('jquery_loadinganimation_close_on_esc', TRUE));
-  return system_settings_form($form);
+<?php
+
+/**
+ * @file
+ * JQuery Loadinganimation admin/configuration functionality.
+ */
+
+/**
+ * jquery_loadinganimation admin settings form.
+ */
+function jquery_loadinganimation_settings_form() {
+  $module_path = drupal_get_path('module', 'jquery_loadinganimation');
+  $img_src_default = $module_path . '/images/ajax-loader.gif';
+  $form['jquery_loadinganimation_show_on_ajax'] = array(
+    '#type' => 'checkbox',
+    '#title' => t('Show during AJAX requests'),
+    '#description' => t(
+        "Display the loading animation during AJAX requests too. Notice: Use with caution, may be disturbing."),
+    '#default_value' => variable_get('jquery_loadinganimation_show_on_ajax', FALSE));
+  $form['jquery_loadinganimation_show_on_form_submit'] = array(
+    '#type' => 'checkbox',
+    '#title' => t('Show after form submission'),
+    '#description' => t("Display the loading animation on form submit. <em>Important:</em> Buttons with further JS events registered are excluded from this trigger."),
+    '#default_value' => variable_get(
+        'jquery_loadinganimation_show_on_form_submit', TRUE));
+  $form['jquery_loadinganimation_show_on_href'] = array(
+    '#type' => 'checkbox',
+    '#title' => t('Show on href click'),
+    '#description' => t(
+        "Display the loading animation after a link has been clicked."),
+    '#default_value' => variable_get('jquery_loadinganimation_show_on_href', TRUE));
+  $form['jquery_loadinganimation_subselector'] = array(
+    '#type' => 'textfield',
+    '#title' => t('JQuery subselector'),
+    '#description' => t(
+        "You may optionally use this subselector to reduce the DOM context which to register loading animation to."),
+    '#required' => FALSE,
+    '#default_value' => variable_get('jquery_loadinganimation_subselector', ''));
+  // Exclude
+  $form['jquery_loadinganimation_path_match_exclude'] = array(
+    '#type' => 'textarea',
+    '#title' => t('Exclude the following path(s)'),
+    '#description' => t(
+        "jQuery Loadinganimation will not be used for paths that match these patterns.") . ' ' . t("Specify pages by using their paths. Enter one path per line. The '*' character is a wildcard. Example paths are %blog for the blog page and %blog-wildcard for every personal blog. %front is the front page.") . ' ' . t("Default: 'admin/*'"),
+    '#required' => TRUE,
+    '#default_value' => variable_get('jquery_loadinganimation_path_match_exclude', ''));
+  $form['jquery_loadinganimation_close_on_click'] = array(
+    '#type' => 'checkbox',
+    '#title' => t('Close on layer click'),
+    '#description' => t(
+        "Close the layer if user clicks on it while loading process is still in progress."),
+    '#default_value' => variable_get('jquery_loadinganimation_close_on_click', TRUE));
+  $form['jquery_loadinganimation_close_on_esc'] = array(
+    '#type' => 'checkbox',
+    '#title' => t('Close on ESC press'),
+    '#description' => t(
+        "Close the layer if user presses ESC while loading process is still in progress."),
+    '#default_value' => variable_get('jquery_loadinganimation_close_on_esc', TRUE));
+  return system_settings_form($form);
 }
\ No newline at end of file

jquery_loadinganimation.install

@@ -16,6 +16,15 @@ function jquery_loadinganimation_install() {
   variable_set('jquery_loadinganimation_close_on_click', TRUE);
   variable_set('jquery_loadinganimation_close_on_esc', TRUE);
   variable_set('jquery_loadinganimation_subselector', '');
+  /*
+   * By default exclude the following path:
+   * admin/ *
+   * panels/ *
+   * node/ * /panelizer
+   * js/ *
+   * ajax/ *
+   */
+  variable_set('jquery_loadinganimation_path_match_exclude', "admin/*\npanels/*\nnode/*/panelizer/*\njs/*\najax/*");
 }
 
 /**