diff --git a/core/includes/install.core.inc b/core/includes/install.core.inc
index fe8be4526366f390a888ee203c052e1c9599a3b9..6c492363da7756bec0dc45d459f2f88a1f1ff63e 100644
--- a/core/includes/install.core.inc
+++ b/core/includes/install.core.inc
@@ -1723,7 +1723,8 @@ function install_download_additional_translations_operations(&$install_state) {
  *   The batch definition, if there are language files to import.
  */
 function install_import_translations(&$install_state) {
-  \Drupal::moduleHandler()->loadInclude('locale', 'translation.inc');
+  $module_handler = \Drupal::moduleHandler();
+  $module_handler->loadInclude('locale', 'inc', 'locale.translation');
 
   // If there is more than one language or the single one is not English, we
   // should import translations.
@@ -1741,7 +1742,7 @@ function install_import_translations(&$install_state) {
       $operations[] = ['locale_translation_batch_fetch_import', ['drupal', $language->getId(), []]];
     }
 
-    module_load_include('fetch.inc', 'locale');
+    $module_handler->loadInclude('locale', 'inc', 'locale.fetch');
     $batch = [
       'operations' => $operations,
       'title' => t('Updating translations.'),
@@ -1763,7 +1764,8 @@ function install_import_translations(&$install_state) {
  *   Server access pattern (to replace language code, version number, etc. in).
  */
 function _install_prepare_import($langcodes, $server_pattern) {
-  \Drupal::moduleHandler()->loadInclude('locale', 'bulk.inc');
+  $module_handler = \Drupal::moduleHandler();
+  $module_handler->loadInclude('locale', 'inc', 'locale.bulk');
   $matches = [];
 
   foreach ($langcodes as $langcode) {
@@ -1790,7 +1792,7 @@ function _install_prepare_import($langcodes, $server_pattern) {
             'status' => 1,
           ];
           \Drupal::service('locale.project')->set($data['name'], $data);
-          module_load_include('compare.inc', 'locale');
+          $module_handler->loadInclude('locale', 'inc', 'locale.compare');
           // Reset project information static cache so that it uses the data
           // set above.
           locale_translation_clear_cache_projects();
diff --git a/core/includes/module.inc b/core/includes/module.inc
index a328b436f3e40bc887ac1d6c1ce3fc212780b957..d718a31492be3468fe5598713e21824576cb38dd 100644
--- a/core/includes/module.inc
+++ b/core/includes/module.inc
@@ -20,7 +20,16 @@ function module_load_install($module) {
   // Make sure the installation API is available
   include_once __DIR__ . '/install.inc';
 
-  return module_load_include('install', $module);
+  if (\Drupal::hasService('extension.list.module')) {
+    /** @var \Drupal\Core\Extension\ModuleExtensionList $module_list */
+    $module_list = \Drupal::service('extension.list.module');
+    $file = DRUPAL_ROOT . '/' . $module_list->getPath($module) . "/$module.install";
+    if (is_file($file)) {
+      require_once $file;
+      return $file;
+    }
+  }
+  return FALSE;
 }
 
 /**
@@ -47,15 +56,18 @@ function module_load_install($module) {
  *   (optional) The base file name (without the $type extension). If omitted,
  *   $module is used; i.e., resulting in "$module.$type" by default.
  *
- * @return
+ * @return string|false
  *   The name of the included file, if successful; FALSE otherwise.
  *
- * @todo The module_handler service has a loadInclude() method which performs
- *   this same task but only for enabled modules. Figure out a way to move this
- *   functionality entirely into the module_handler while keeping the ability to
- *   load the files of disabled modules.
+ * @deprecated in drupal:9.4.0 and is removed from drupal:11.0.0.
+ *   Use \Drupal::moduleHandler()->loadInclude($module, $type, $name = NULL).
+ *   Note that including code from uninstalled extensions is no longer
+ *   supported.
+ *
+ * @see https://www.drupal.org/node/2948698
  */
 function module_load_include($type, $module, $name = NULL) {
+  @trigger_error("module_load_include() is deprecated in drupal:9.4.0 and is removed from drupal:11.0.0. Instead, you should use \Drupal::moduleHandler()->loadInclude(). Note that including code from uninstalled extensions is no longer supported. See https://www.drupal.org/project/drupal/issues/697946", E_USER_DEPRECATED);
   if (!isset($name)) {
     $name = $module;
   }
diff --git a/core/includes/update.inc b/core/includes/update.inc
index 7aed4b1a492df2e786503325c1021032e4b96ba7..7c37673f915780e250585254046626d83b2b10d6 100644
--- a/core/includes/update.inc
+++ b/core/includes/update.inc
@@ -287,7 +287,7 @@ function update_invoke_post_update($function, &$context) {
   }
 
   [$module, $name] = explode('_post_update_', $function, 2);
-  module_load_include('php', $module, $module . '.post_update');
+  \Drupal::moduleHandler()->loadInclude($module, 'php', $module . '.post_update');
   if (function_exists($function)) {
     try {
       $ret['results']['query'] = $function($context['sandbox']);
diff --git a/core/lib/Drupal/Core/Form/FormState.php b/core/lib/Drupal/Core/Form/FormState.php
index e52ac646773c3584cb6b13762ba8d0ebcc640ff7..c4e76a4de4009b83c4fd95766c833dfb3024555b 100644
--- a/core/lib/Drupal/Core/Form/FormState.php
+++ b/core/lib/Drupal/Core/Form/FormState.php
@@ -46,10 +46,11 @@ class FormState implements FormStateInterface {
    *   - files: An optional array defining include files that need to be loaded
    *     for building the form. Each array entry may be the path to a file or
    *     another array containing values for the parameters 'type', 'module' and
-   *     'name' as needed by module_load_include(). The files listed here are
-   *     automatically loaded by \Drupal::formBuilder()->getCache(). By default
-   *     the current menu router item's 'file' definition is added, if any. Use
-   *     self::loadInclude() to add include files from a form constructor.
+   *     'name' as needed by \Drupal::moduleHandler()->loadInclude(). The files
+   *     listed here are automatically loaded by
+   *     \Drupal::formBuilder()->getCache(). By default the current menu router
+   *     item's 'file' definition is added, if any. Use self::loadInclude() to
+   *     add include files from a form constructor.
    *   - form_id: Identification of the primary form being constructed and
    *     processed.
    *   - base_form_id: Identification for a base form, as declared in the form
diff --git a/core/lib/Drupal/Core/Form/FormStateInterface.php b/core/lib/Drupal/Core/Form/FormStateInterface.php
index b5790cf04a1561d275ac25cb0625308f7017720d..8b608b9e0417d2b562895ae238578ecc6e916ab1 100644
--- a/core/lib/Drupal/Core/Form/FormStateInterface.php
+++ b/core/lib/Drupal/Core/Form/FormStateInterface.php
@@ -49,11 +49,11 @@ public function setCompleteForm(array &$complete_form);
    *   $form_state->loadInclude('node', 'inc', 'node.admin');
    * @endcode
    *
-   * Use this function instead of module_load_include() from inside a form
-   * constructor or any form processing logic as it ensures that the include file
-   * is loaded whenever the form is processed. In contrast to using
-   * module_load_include() directly, this method makes sure the include file is
-   * correctly loaded also if the form is cached.
+   * Use this function instead of \Drupal::moduleHandler()->loadInclude()
+   * from inside a form constructor or any form processing logic as it ensures
+   * that the include file is loaded whenever the form is processed. In contrast
+   * to using \Drupal::moduleHandler()->loadInclude() directly, this method
+   * makes sure the include file is correctly loaded also if the form is cached.
    *
    * @param string $module
    *   The module to which the include file belongs.
@@ -67,7 +67,7 @@ public function setCompleteForm(array &$complete_form);
    *   The filepath of the loaded include file, or FALSE if the include file was
    *   not found or has been loaded already.
    *
-   * @see module_load_include()
+   * @see \Drupal\Core\Extension\ModuleHandlerInterface::loadInclude()
    */
   public function loadInclude($module, $type, $name = NULL);
 
diff --git a/core/lib/Drupal/Core/Updater/Module.php b/core/lib/Drupal/Core/Updater/Module.php
index 17e02f098c4a74ad2d3ed505ea57bd1c008a506f..66e92517560eaa30e2bb684e233558cd11dc591f 100644
--- a/core/lib/Drupal/Core/Updater/Module.php
+++ b/core/lib/Drupal/Core/Updater/Module.php
@@ -87,7 +87,7 @@ public function getSchemaUpdates() {
     if (!self::canUpdate($this->name)) {
       return [];
     }
-    module_load_include('install', $this->name);
+    \Drupal::moduleHandler()->loadInclude($this->name, 'install');
 
     if (!\Drupal::service('update.update_hook_registry')->getAvailableUpdates($this->name)) {
       return [];
diff --git a/core/modules/content_translation/content_translation.module b/core/modules/content_translation/content_translation.module
index ec649e533f8cbc39cc5cae2f7477835daab3b131..1d5ef947b594e3958a39415bae115d5238612bb8 100644
--- a/core/modules/content_translation/content_translation.module
+++ b/core/modules/content_translation/content_translation.module
@@ -507,7 +507,7 @@ function content_translation_form_field_config_edit_form_alter(array &$form, For
   }
 
   if ($field->isTranslatable()) {
-    module_load_include('inc', 'content_translation', 'content_translation.admin');
+    \Drupal::moduleHandler()->loadInclude('content_translation', 'inc', 'content_translation.admin');
     $element = content_translation_field_sync_widget($field);
     if ($element) {
       $form['third_party_settings']['content_translation']['translation_sync'] = $element;
@@ -651,7 +651,7 @@ function content_translation_language_configuration_element_submit(array $form,
  * Implements hook_form_FORM_ID_alter() for language_content_settings_form().
  */
 function content_translation_form_language_content_settings_form_alter(array &$form, FormStateInterface $form_state) {
-  module_load_include('inc', 'content_translation', 'content_translation.admin');
+  \Drupal::moduleHandler()->loadInclude('content_translation', 'inc', 'content_translation.admin');
   _content_translation_form_language_content_settings_form_alter($form, $form_state);
 }
 
@@ -659,7 +659,7 @@ function content_translation_form_language_content_settings_form_alter(array &$f
  * Implements hook_preprocess_HOOK() for language-content-settings-table.html.twig.
  */
 function content_translation_preprocess_language_content_settings_table(&$variables) {
-  module_load_include('inc', 'content_translation', 'content_translation.admin');
+  \Drupal::moduleHandler()->loadInclude('content_translation', 'inc', 'content_translation.admin');
   _content_translation_preprocess_language_content_settings_table($variables);
 }
 
diff --git a/core/modules/locale/locale.batch.inc b/core/modules/locale/locale.batch.inc
index 8b3fe6ac434aeaec8a400c95230df9e13aa83f88..106bc62b7ae1387126213604ad4f04b77adec99d 100644
--- a/core/modules/locale/locale.batch.inc
+++ b/core/modules/locale/locale.batch.inc
@@ -182,7 +182,7 @@ function locale_translation_batch_fetch_import($project, $langcode, $options, &$
     if (isset($source->type)) {
       if ($source->type == LOCALE_TRANSLATION_REMOTE || $source->type == LOCALE_TRANSLATION_LOCAL) {
         $file = $source->files[LOCALE_TRANSLATION_LOCAL];
-        module_load_include('bulk.inc', 'locale');
+        \Drupal::moduleHandler()->loadInclude('locale', 'inc', 'locale.bulk');
         $options += [
           'message' => t('Importing %langcode translation for %project.', ['%langcode' => $langcode, '%project' => $source->project]),
         ];
@@ -217,7 +217,7 @@ function locale_translation_batch_fetch_import($project, $langcode, $options, &$
  *   Batch results.
  */
 function locale_translation_batch_fetch_finished($success, $results) {
-  module_load_include('bulk.inc', 'locale');
+  \Drupal::moduleHandler()->loadInclude('locale', 'inc', 'locale.bulk');
   if ($success) {
     \Drupal::state()->set('locale.translation_last_checked', REQUEST_TIME);
   }
diff --git a/core/modules/locale/locale.bulk.inc b/core/modules/locale/locale.bulk.inc
index b4f70a4be6d6a66fda10598ca900fd4665d404af..d4a68e0bf00eecf4faa621a00f43a2331e6dd37f 100644
--- a/core/modules/locale/locale.bulk.inc
+++ b/core/modules/locale/locale.bulk.inc
@@ -88,7 +88,7 @@ function locale_translate_batch_import_files(array $options, $force = FALSE) {
  *   An array of interface translation files keyed by their URI.
  */
 function locale_translate_get_interface_translation_files(array $projects = [], array $langcodes = []) {
-  module_load_include('compare.inc', 'locale');
+  \Drupal::moduleHandler()->loadInclude('locale', 'inc', 'locale.compare');
   $files = [];
   $projects = $projects ? $projects : array_keys(locale_translation_get_projects());
   $langcodes = $langcodes ? $langcodes : array_keys(locale_translatable_language_list());
diff --git a/core/modules/locale/locale.fetch.inc b/core/modules/locale/locale.fetch.inc
index 89114ccc21879f4b70288c6b239b86168ff46c6f..a6a9b36689abba9d3f1d0ec34b96ef139c024b48 100644
--- a/core/modules/locale/locale.fetch.inc
+++ b/core/modules/locale/locale.fetch.inc
@@ -29,7 +29,7 @@
  *   Batch definition array.
  */
 function locale_translation_batch_update_build($projects = [], $langcodes = [], $options = []) {
-  module_load_include('compare.inc', 'locale');
+  \Drupal::moduleHandler()->loadInclude('locale', 'inc', 'locale.compare');
   $projects = $projects ? $projects : array_keys(locale_translation_get_projects());
   $langcodes = $langcodes ? $langcodes : array_keys(locale_translatable_language_list());
   $status_options = $options;
diff --git a/core/modules/locale/locale.module b/core/modules/locale/locale.module
index c781ec0f46ecdfbcce68d3c883d0dbf36c29bc15..1fffee3bcface91e265d0927ce67c15a96043180 100644
--- a/core/modules/locale/locale.module
+++ b/core/modules/locale/locale.module
@@ -231,7 +231,7 @@ function locale_configurable_language_delete(ConfigurableLanguageInterface $lang
   \Drupal::service('locale.storage')->deleteTranslations(['language' => $language->id()]);
 
   // Remove interface translation files.
-  module_load_include('inc', 'locale', 'locale.bulk');
+  \Drupal::moduleHandler()->loadInclude('locale', 'inc', 'locale.bulk');
   locale_translate_delete_translation_files([], [$language->id()]);
 
   // Remove translated configuration objects.
@@ -359,7 +359,7 @@ function locale_cron() {
   // and a translatable language was set.
   // Update tasks are added to the queue here but processed by Drupal's cron.
   if (\Drupal::config('locale.settings')->get('translation.update_interval_days') && locale_translatable_language_list()) {
-    module_load_include('translation.inc', 'locale');
+    \Drupal::moduleHandler()->loadInclude('locale', 'inc', 'locale.translation');
     locale_cron_fill_queue();
   }
 }
@@ -410,15 +410,16 @@ function locale_system_update(array $components) {
   // because it would break out of the installer flow. We have
   // built-in support for translation imports in the installer.
   if (!InstallerKernel::installationAttempted() && locale_translatable_language_list()) {
+    $module_handler = \Drupal::moduleHandler();
     if (\Drupal::config('locale.settings')->get('translation.import_enabled')) {
-      module_load_include('compare.inc', 'locale');
+      $module_handler->loadInclude('locale', 'inc', 'locale.compare');
 
       // Update the list of translatable projects and start the import batch.
       // Only when new projects are added the update batch will be triggered.
       // Not each enabled module will introduce a new project. E.g. sub modules.
       $projects = array_keys(locale_translation_build_projects());
       if ($list = array_intersect($list, $projects)) {
-        module_load_include('fetch.inc', 'locale');
+        $module_handler->loadInclude('locale', 'inc', 'locale.fetch');
         // Get translation status of the projects, download and update
         // translations.
         $options = _locale_translation_default_update_options();
@@ -431,7 +432,7 @@ function locale_system_update(array $components) {
     // this component may have installed configuration from any number of other
     // components. Do this even if import is not enabled because parsing new
     // configuration may expose new source strings.
-    \Drupal::moduleHandler()->loadInclude('locale', 'bulk.inc');
+    $module_handler->loadInclude('locale', 'inc', 'locale.bulk');
     if ($batch = locale_config_batch_update_components([])) {
       batch_set($batch);
     }
@@ -453,8 +454,9 @@ function locale_system_remove($components) {
   $components += ['module' => [], 'theme' => []];
   $list = array_merge($components['module'], $components['theme']);
   if (locale_translatable_language_list()) {
-    module_load_include('compare.inc', 'locale');
-    \Drupal::moduleHandler()->loadInclude('locale', 'bulk.inc');
+    $module_handler = \Drupal::moduleHandler();
+    $module_handler->loadInclude('locale', 'inc', 'locale.compare');
+    $module_handler->loadInclude('locale', 'inc', 'locale.bulk');
 
     // Only when projects are removed, the translation files and records will be
     // deleted. Not each disabled module will remove a project, e.g., sub
@@ -863,7 +865,7 @@ function locale_translation_file_history_delete($projects = [], $langcodes = [])
 function locale_translation_get_status($projects = NULL, $langcodes = NULL) {
   $result = [];
   $status = \Drupal::keyValue('locale.translation_status')->getAll();
-  module_load_include('translation.inc', 'locale');
+  \Drupal::moduleHandler()->loadInclude('locale', 'inc', 'locale.translation');
   $projects = $projects ? $projects : array_keys(locale_translation_get_projects());
   $langcodes = $langcodes ? $langcodes : array_keys(locale_translatable_language_list());
 
@@ -899,7 +901,7 @@ function locale_translation_get_status($projects = NULL, $langcodes = NULL) {
  */
 function locale_translation_status_save($project, $langcode, $type, $data) {
   // Load the translation status or build it if not already available.
-  module_load_include('translation.inc', 'locale');
+  \Drupal::moduleHandler()->loadInclude('locale', 'inc', 'locale.translation');
   $status = locale_translation_get_status();
   if (empty($status)) {
     $projects = locale_translation_get_projects([$project]);
diff --git a/core/modules/locale/locale.translation.inc b/core/modules/locale/locale.translation.inc
index 74667cf1fe3adfaf58b392e8d198e4c44de84846..efd1aad13be4963b55ac02e8dab07b9789e0a2e6 100644
--- a/core/modules/locale/locale.translation.inc
+++ b/core/modules/locale/locale.translation.inc
@@ -63,7 +63,7 @@ function locale_translation_get_projects(array $project_names = []) {
     // https://www.drupal.org/node/1777106 is a follow-up issue to make the
     // check for possible out-of-date project information more robust.
     if ($row_count == 0) {
-      module_load_include('compare.inc', 'locale');
+      \Drupal::moduleHandler()->loadInclude('locale', 'inc', 'locale.compare');
       // At least the core project should be in the database, so we build the
       // data if none are found.
       locale_translation_build_projects();
@@ -357,7 +357,7 @@ function locale_cron_fill_queue() {
   // For each project+language combination a number of tasks are added to
   // the queue.
   if ($updates) {
-    module_load_include('fetch.inc', 'locale');
+    \Drupal::moduleHandler()->loadInclude('locale', 'inc', 'locale.fetch');
     $options = _locale_translation_default_update_options();
     $queue = \Drupal::queue('locale_translation', TRUE);
 
diff --git a/core/modules/locale/tests/src/Functional/LocaleUpdateDevelopmentReleaseTest.php b/core/modules/locale/tests/src/Functional/LocaleUpdateDevelopmentReleaseTest.php
index 02a732774264c306d78ff479c8219172926cc585..0d443d40dfac707de6b840c5e07a7e03162b9246 100644
--- a/core/modules/locale/tests/src/Functional/LocaleUpdateDevelopmentReleaseTest.php
+++ b/core/modules/locale/tests/src/Functional/LocaleUpdateDevelopmentReleaseTest.php
@@ -20,7 +20,7 @@ class LocaleUpdateDevelopmentReleaseTest extends BrowserTestBase {
 
   protected function setUp(): void {
     parent::setUp();
-    module_load_include('compare.inc', 'locale');
+    \Drupal::moduleHandler()->loadInclude('locale', 'inc', 'locale.compare');
     $admin_user = $this->drupalCreateUser([
       'administer modules',
       'administer languages',
diff --git a/core/modules/locale/tests/src/Functional/LocaleUpdateTest.php b/core/modules/locale/tests/src/Functional/LocaleUpdateTest.php
index a833b5be3d73a8abb8f2d07f8b80ee008467f24c..1091bb5e923053ba4da839a5a6e568573f284b5b 100644
--- a/core/modules/locale/tests/src/Functional/LocaleUpdateTest.php
+++ b/core/modules/locale/tests/src/Functional/LocaleUpdateTest.php
@@ -22,8 +22,9 @@ class LocaleUpdateTest extends LocaleUpdateBase {
    */
   protected function setUp(): void {
     parent::setUp();
-    module_load_include('compare.inc', 'locale');
-    module_load_include('fetch.inc', 'locale');
+    $module_handler = \Drupal::moduleHandler();
+    $module_handler->loadInclude('locale', 'inc', 'locale.compare');
+    $module_handler->loadInclude('locale', 'inc', 'locale.fetch');
     $admin_user = $this->drupalCreateUser([
       'administer modules',
       'administer site configuration',
diff --git a/core/modules/node/node.module b/core/modules/node/node.module
index cc32fef1376ae15759a83d97c214cf870842254a..f85e839584c18aa6339d8d3f25252a40969042bc 100644
--- a/core/modules/node/node.module
+++ b/core/modules/node/node.module
@@ -640,13 +640,13 @@ function node_user_cancel($edit, UserInterface $account, $method) {
         ->accessCheck(FALSE)
         ->condition('uid', $account->id())
         ->execute();
-      module_load_include('inc', 'node', 'node.admin');
+      \Drupal::moduleHandler()->loadInclude('node', 'inc', 'node.admin');
       node_mass_update($nids, ['status' => 0], NULL, TRUE);
       break;
 
     case 'user_cancel_reassign':
       // Anonymize all of the nodes for this old account.
-      module_load_include('inc', 'node', 'node.admin');
+      \Drupal::moduleHandler()->loadInclude('node', 'inc', 'node.admin');
       $vids = \Drupal::entityTypeManager()->getStorage('node')->userRevisionIds($account);
       node_mass_update($vids, [
         'uid' => 0,
diff --git a/core/modules/system/tests/modules/entity_test/entity_test.install b/core/modules/system/tests/modules/entity_test/entity_test.install
index 9a846afd62f5d149744630992b67be9f3212f35a..4b606192f484201c24912202d4d1141fd48f769f 100644
--- a/core/modules/system/tests/modules/entity_test/entity_test.install
+++ b/core/modules/system/tests/modules/entity_test/entity_test.install
@@ -54,7 +54,8 @@ function entity_test_schema() {
   return $schema;
 }
 
+$module_handler = \Drupal::moduleHandler();
 $index = \Drupal::state()->get('entity_test.db_updates.entity_definition_updates');
-module_load_include('inc', 'entity_test', 'update/entity_definition_updates_' . $index);
+$module_handler->loadInclude('entity_test', 'inc', 'update/entity_definition_updates_' . $index);
 $index = \Drupal::state()->get('entity_test.db_updates.status_report');
-module_load_include('inc', 'entity_test', 'update/status_report_' . $index);
+$module_handler->loadInclude('entity_test', 'inc', 'update/status_report_' . $index);
diff --git a/core/modules/update/tests/src/Functional/UpdateContribTest.php b/core/modules/update/tests/src/Functional/UpdateContribTest.php
index f00934dd9fd185a1820c6ae8fcc094f54be37368..6b732f0ebc3f60cb7780d79b159ab22bc143c240 100644
--- a/core/modules/update/tests/src/Functional/UpdateContribTest.php
+++ b/core/modules/update/tests/src/Functional/UpdateContribTest.php
@@ -418,7 +418,7 @@ public function testUpdateShowDisabledThemes() {
    * Tests updates with a hidden base theme.
    */
   public function testUpdateHiddenBaseTheme() {
-    module_load_include('compare.inc', 'update');
+    \Drupal::moduleHandler()->loadInclude('update', 'inc', 'update.compare');
 
     // Install the subtheme.
     \Drupal::service('theme_installer')->install(['update_test_subtheme']);
diff --git a/core/modules/update/update.install b/core/modules/update/update.install
index 4c4fdc1633bc1ba4812a8788c703b2a27456a16a..ed845df6fdda0d1dfd5658ca7d3b4f2789f649bd 100644
--- a/core/modules/update/update.install
+++ b/core/modules/update/update.install
@@ -36,7 +36,7 @@ function update_requirements($phase) {
   $requirements = [];
   if ($phase == 'runtime') {
     if ($available = update_get_available(FALSE)) {
-      module_load_include('inc', 'update', 'update.compare');
+      \Drupal::moduleHandler()->loadInclude('update', 'inc', 'update.compare');
       $data = update_calculate_project_data($available);
       // First, populate the requirements for core:
       $requirements['update_core'] = _update_requirement_check($data['drupal'], 'core');
diff --git a/core/modules/update/update.module b/core/modules/update/update.module
index b01eb0e77179ddabed8101459915d04f24af77a6..7a1a927ab7c32bca38ec3daf68e560c0e0ee31e5 100644
--- a/core/modules/update/update.module
+++ b/core/modules/update/update.module
@@ -193,7 +193,7 @@ function update_cron() {
   if ((REQUEST_TIME - $last_email_notice) > $interval) {
     // If configured time between notifications elapsed, send email about
     // updates possibly available.
-    module_load_include('inc', 'update', 'update.fetch');
+    \Drupal::moduleHandler()->loadInclude('update', 'inc', 'update.fetch');
     _update_cron_notify();
   }
 
@@ -276,7 +276,7 @@ function _update_no_data() {
  * @see \Drupal\update\UpdateManager::getProjects()
  */
 function update_get_available($refresh = FALSE) {
-  module_load_include('inc', 'update', 'update.compare');
+  \Drupal::moduleHandler()->loadInclude('update', 'inc', 'update.compare');
   $needs_refresh = FALSE;
 
   // Grab whatever data we currently have.
diff --git a/core/modules/user/user.api.php b/core/modules/user/user.api.php
index 65b4d5cdfdcebcca73c141f77e8c142e689fb4cc..b0b639afbfe4147c55371e6135b22d9937f4e8ba 100644
--- a/core/modules/user/user.api.php
+++ b/core/modules/user/user.api.php
@@ -43,7 +43,7 @@ function hook_user_cancel($edit, UserInterface $account, $method) {
   switch ($method) {
     case 'user_cancel_block_unpublish':
       // Unpublish nodes (current revisions).
-      module_load_include('inc', 'node', 'node.admin');
+      \Drupal::moduleHandler()->loadInclude('node', 'inc', 'node.admin');
       $nodes = \Drupal::entityQuery('node')
         ->accessCheck(FALSE)
         ->condition('uid', $account->id())
@@ -53,7 +53,7 @@ function hook_user_cancel($edit, UserInterface $account, $method) {
 
     case 'user_cancel_reassign':
       // Anonymize nodes (current revisions).
-      module_load_include('inc', 'node', 'node.admin');
+      \Drupal::moduleHandler()->loadInclude('node', 'inc', 'node.admin');
       $nodes = \Drupal::entityQuery('node')
         ->accessCheck(FALSE)
         ->condition('uid', $account->id())
diff --git a/core/modules/views/src/Plugin/views/wizard/WizardPluginBase.php b/core/modules/views/src/Plugin/views/wizard/WizardPluginBase.php
index 0488df1c0434d7cd093bb66eef25bf31aa4ba6ef..2aa71a94a8ffe23d0ec7df1aafcf4749748744f5 100644
--- a/core/modules/views/src/Plugin/views/wizard/WizardPluginBase.php
+++ b/core/modules/views/src/Plugin/views/wizard/WizardPluginBase.php
@@ -623,7 +623,7 @@ protected function rowStyleOptions() {
    * available).
    */
   protected function buildFilters(&$form, FormStateInterface $form_state) {
-    module_load_include('inc', 'views_ui', 'admin');
+    \Drupal::moduleHandler()->loadInclude('views_ui', 'inc', 'admin');
 
     $bundles = $this->bundleInfoService->getBundleInfo($this->entityTypeId);
     // If the current base table support bundles and has more than one (like user).
@@ -928,7 +928,7 @@ protected function defaultDisplayFiltersUser(array $form, FormStateInterface $fo
       // Figure out the table where $bundle_key lives. It may not be the same as
       // the base table for the view; the taxonomy vocabulary machine_name, for
       // example, is stored in taxonomy_vocabulary, not taxonomy_term_data.
-      module_load_include('inc', 'views_ui', 'admin');
+      \Drupal::moduleHandler()->loadInclude('views_ui', 'inc', 'admin');
       $fields = Views::viewsDataHelper()->fetchFields($this->base_table, 'filter');
       $table = FALSE;
       if (isset($fields[$this->base_table . '.' . $bundle_key])) {
diff --git a/core/tests/Drupal/KernelTests/Core/Extension/ModuleLegacyTest.php b/core/tests/Drupal/KernelTests/Core/Extension/ModuleLegacyTest.php
new file mode 100644
index 0000000000000000000000000000000000000000..1b281c286a7297fc74e32e0fe036837021122a96
--- /dev/null
+++ b/core/tests/Drupal/KernelTests/Core/Extension/ModuleLegacyTest.php
@@ -0,0 +1,25 @@
+<?php
+
+namespace Drupal\KernelTests\Core\Extension;
+
+use Drupal\KernelTests\KernelTestBase;
+
+/**
+ * Tests deprecations from module.inc file.
+ *
+ * @group legacy
+ */
+class ModuleLegacyTest extends KernelTestBase {
+
+  /**
+   * Test deprecation of module_load_include() function.
+   */
+  public function testModuleLoadInclude() {
+    $this->assertFalse($this->container->get('module_handler')->moduleExists('module_test'), 'Ensure module is uninstalled so we test the ability to include uninstalled code.');
+    $this->expectDeprecation('module_load_include() is deprecated in drupal:9.4.0 and is removed from drupal:11.0.0. Instead, you should use \Drupal::moduleHandler()->loadInclude(). Note that including code from uninstalled extensions is no longer supported. See https://www.drupal.org/project/drupal/issues/697946');
+    $filename = module_load_include('inc', 'module_test', 'module_test.file');
+    $this->assertStringEndsWith("module_test.file.inc", $filename);
+
+  }
+
+}