diff --git a/core/lib/Drupal/Core/Entity/ContentEntityStorageBase.php b/core/lib/Drupal/Core/Entity/ContentEntityStorageBase.php
index 17a5d3bfdb8618fbed9d0da0a5aac2821af050e7..7e18e5bca1f4ad191abdc62ac9a0e93519a5bc04 100644
--- a/core/lib/Drupal/Core/Entity/ContentEntityStorageBase.php
+++ b/core/lib/Drupal/Core/Entity/ContentEntityStorageBase.php
@@ -1113,9 +1113,14 @@ protected function setPersistentCache($entities) {
       $this->entityTypeId . '_values',
       'entity_field_info',
     ];
+    $items = [];
     foreach ($entities as $id => $entity) {
-      $this->cacheBackend->set($this->buildCacheId($id), $entity, CacheBackendInterface::CACHE_PERMANENT, $cache_tags);
+      $items[$this->buildCacheId($id)] = [
+        'data' => $entity,
+        'tags' => $cache_tags,
+      ];
     }
+    $this->cacheBackend->setMultiple($items);
   }
 
   /**
diff --git a/core/tests/Drupal/Tests/Core/Entity/Sql/SqlContentEntityStorageTest.php b/core/tests/Drupal/Tests/Core/Entity/Sql/SqlContentEntityStorageTest.php
index 185a68eda056e06b159c41095dcad85902db9b77..f256245a6786ac2b78c8f71956c54e0659844d83 100644
--- a/core/tests/Drupal/Tests/Core/Entity/Sql/SqlContentEntityStorageTest.php
+++ b/core/tests/Drupal/Tests/Core/Entity/Sql/SqlContentEntityStorageTest.php
@@ -7,7 +7,6 @@
 
 namespace Drupal\Tests\Core\Entity\Sql;
 
-use Drupal\Core\Cache\CacheBackendInterface;
 use Drupal\Core\Cache\MemoryCache\MemoryCache;
 use Drupal\Core\DependencyInjection\ContainerBuilder;
 use Drupal\Core\Entity\EntityFieldManager;
@@ -1296,8 +1295,13 @@ public function testLoadMultiplePersistentCacheMiss() {
       ->with([$key])
       ->willReturn([]);
     $this->cache->expects($this->once())
-      ->method('set')
-      ->with($key, $entity, CacheBackendInterface::CACHE_PERMANENT, [$this->entityTypeId . '_values', 'entity_field_info']);
+      ->method('setMultiple')
+      ->with([
+        $key => [
+          'data' => $entity,
+          'tags' => [$this->entityTypeId . '_values', 'entity_field_info'],
+        ],
+      ]);
 
     $this->entityTypeManager->expects($this->any())
       ->method('getActiveDefinition')